Resources for COVID-19 (updated 2021-05-13)

Special populations

The infection with SARS-CoV-2 virus and the COVID-19 disease caused by the virus can be a serious health threat for special populations such as children and patients with cancer .

Safe and effective treatments and vaccines increasingly become available. This page collects information on plans, ongoing trials and results with COVID-19 treatments and SARS-CoV-2 vaccines for children and patients with cancer, by means of references to official or quality information on the internet.

Study plans

New medicines are required to be developed for children (see background in this blog). Here are the clinical trials with children and other studies to investigate medicines to treat or prevent (vaccines) COVID-19 in children (click on tab "Studies" to see details):

Authorised medicines

Medicines that were investigated and now have been authorised to treat or prevent (vaccines) COVID-19 by the European Medicines Agency (EMA) are listed on their webpage here, and such centrally authorised medicines are here:

Medical care resources

For children, and for adults and children with cancer, learned societies and other quality information providers make available recommendations, some of which are listed here, together with reviews and updates on COVID-19:

Vaccine trials and recommendations

Immunocompromised individuals are addressed in the section 4.4 Special warnings and precautions of each of the 4 authorised COVID-19 vaccines:

Recommendations have been published by cancer societies on the use of COVID-19 vaccines in immunosuppressed patients, in particular:

In their rolling blog, Cancer Research UK discuss trials and how patients with cancer may have taken part so far, as well as observational studies and the limited data that are available so far (https://scienceblog.cancerresearchuk.org/covid-19-vaccine-and-cancer-latest-updates/).

Information about clinical trials (studies) has to be made public, and public registers can be queried in various ways . For vaccines being evaluated by the European Medicines Agency (EMA) by 2021-05-13, the table below lists trials from a public register. Paediatric and adult patients with cancer may be excluded from a trial, for example if its protocol has exclusion criteria that refer to immunocompromised patients or patients with a serious condition. Added to the table is the information if such patients are excluded (columns immunosuppression_excluded, illness_excluded and cancer_excluded) from the respective trial, on the basis of a simple, automated analysis of the eligibility criteria (click below to see the code of the analysis). Use the ctgov_link to check the full eligibility text.

COVID-19 vaccines - interventional trials - created on 2021-05-13 12:20:29
intervention intervention name eligibility minimum age enrollment start date primary completion date immunosuppression excluded illness excluded cancer excluded ctgov link and identifiers
0.9% (w/v) saline / AZD1222 18 Years 256 2020-08-23 2021-11-15 TRUE TRUE TRUE NCT04568031 D8111C00002, NCT04568031
13 cis retinoic acid doses orally in combination with spike protein based vaccine / Aerosolized 13 cis retinoic acid / Aerosolized 13 cis retinoic acid in combination with spike protein based vaccine / Biological: spike protein based vaccine such as ChAdOx1 nCoV-19 vaccine / Oral 13 cis retinoic acid 18 Years 360 2021-02-15 2021-04-15 TRUE TRUE FALSE NCT04730895 COVID vaccine, NCT04730895
2 doses of vaccine / 3-doses schedule 1 of COVID-19 Vaccine (Vero Cell), Inactivated / 3-doses schedule 2 of COVID-19 Vaccine (Vero Cell), Inactivated / 3-doses schedule 3 of COVID-19 Vaccine (Vero Cell), Inactivated 3 Years 4400 2021-04-29 2022-03-31 FALSE FALSE TRUE NCT04863638 BIBP2020004CN, NCT04863638
Ad26.COV2.S 18 Years 400 2021-03-12 2023-01-16 FALSE FALSE TRUE NCT04765384 CR108962, 2020-005330-14, VAC31518COV2004, NCT04765384
Ad26.COV2.S / Placebo 18 Years 1085 2020-07-15 2021-12-03 FALSE TRUE TRUE NCT04436276 CR108828, 2020-001483-28, VAC31518COV1001, NCT04436276
Ad26.COV2.S / Placebo 18 Years 44325 2020-09-07 2021-01-22 FALSE TRUE FALSE NCT04505722 CR108876, VAC31518COV3001, NCT04505722
Ad26.COV2.S / Placebo 20 Years 250 2020-08-11 2021-02-22 TRUE TRUE TRUE NCT04509947 CR108871, VAC31518COV1002, NCT04509947
Ad26.COV2.S / Placebo 18 Years 30000 2020-11-16 2022-05-10 FALSE TRUE FALSE NCT04614948 CR108916, 2020-003643-29, VAC31518COV3009, NCT04614948
AZD1222 18 Years 100 2020-09-02 2021-05-11 TRUE TRUE TRUE NCT04540393 D8111C00001, NCT04540393
AZD1222 / BNT162b2 / CoronaVac 18 Years 900 2021-03-15 2021-12-31 FALSE FALSE FALSE NCT04775069 HHCTC_COVID-19_VACCINE_Ab, NCT04775069
AZD1222 / Placebo 18 Years 32459 2020-08-28 2021-03-05 TRUE TRUE FALSE NCT04516746 D8110C00001, NCT04516746
AZD1222 / rAd26-S 18 Years 100 2021-03-30 2021-10-12 TRUE TRUE TRUE NCT04684446 D8111C00003, NCT04684446
AZD1222 / rAd26-S 18 Years 100 2021-02-10 2021-04-09 TRUE TRUE TRUE NCT04686773 AZD1222 - rAd26-S, NCT04686773
AZD1222 / rAd26-S 18 Years 100 2021-03-17 2021-05-01 TRUE TRUE TRUE NCT04760730 CV03872091, NCT04760730
AZD1222 / VLA2001 18 Years 4000 2021-04-26 2021-07-15 FALSE TRUE TRUE NCT04864561 VLA2001-301, NCT04864561
Biological: mRNA-1273 / Placebo / mRNA-1273.351 18 Years 660 2020-05-29 2021-11-01 TRUE TRUE TRUE NCT04405076 mRNA-1273-P201, 75A50120C00034, NCT04405076
BNT162a1 / BNT162b1 / BNT162b2 / BNT162c2 18 Years 476 2020-04-23 2023-04-15 TRUE TRUE TRUE NCT04380701 BNT162-01, 2020-001038-36, U1111-1249-4220, NCT04380701
BNT162b1 / BNT162b2 / BNT162b2SA / Placebo 12 Years 46663 2020-04-29 2021-10-29 TRUE TRUE TRUE NCT04368728 C4591001, 2020-002641-42, NCT04368728
BNT162b1 / Placebo 18 Years 144 2020-07-28 2020-09-30 TRUE TRUE FALSE NCT04523571 BNT162-03, NCT04523571
BNT162b2 12 Years 1530 2021-02-15 2021-05-11 TRUE TRUE TRUE NCT04713553 C4591017, NCT04713553
BNT162b2 18 Years 84 2021-04-01 2021-07-06 TRUE TRUE TRUE NCT04816669 C4591020, NCT04816669
BNT162b2 / Placebo 20 Years 160 2020-10-21 2021-11-30 TRUE TRUE TRUE NCT04588480 C4591005, NCT04588480
BNT162b2 / Placebo 18 Years 950 2020-12-04 2021-12-15 TRUE TRUE TRUE NCT04649021 BNT162-06, NCT04649021
BNT162b2 / Placebo N/A 4000 2021-02-16 2022-06-27 TRUE TRUE TRUE NCT04754594 C4591015, 2020-005444-35, NCT04754594
BNT162b2 20mcg / BNT162b2 30mcg / Biological/Vaccine: BNT162b2 10mcg 6 Months 4644 2021-03-24 2022-03-04 TRUE TRUE TRUE NCT04816643 C4591007, 2020-005442-42, NCT04816643
BNT162b3 18 Years 96 2020-09-09 2021-03-12 TRUE TRUE TRUE NCT04537949 BNT162-04, 2020-003267-26, U1111-1254-4840, NCT04537949
ChAdOx1 nCov-19 18 Years 54 2021-04-01 2022-02-15 TRUE TRUE TRUE NCT04816019 COV008, NCT04816019
ChAdOx1 nCoV-19 (Abs 260) / ChAdOx1 nCoV-19 (Abs 260) + 2.2x10^10vp (qPCR) boost / ChAdOx1 nCoV-19 (qPCR) / ChAdOx1 nCoV-19 0.5mL prime plus boost / MenACWY vaccine / Two dose ChAdOx1 nCoV-19/Covishield 0.25mL & 0.5mL / Two dose ChAdOx1 nCoV-19/Covishield 0.5mL / Two dose MenACWY vaccine / Two dose MenACWY vaccine min. 4 weeks apart 18 Years 12390 2020-05-28 2021-09-15 TRUE TRUE TRUE NCT04400838 COV002, NCT04400838
ChAdOx1 nCoV-19 / ChAdOx1 nCoV-19 0.5mL (3.5-6.5x10^10vp) late vaccine (LV) / ChAdOx1 nCoV-19 0.5mL (3.5-6.5x10^10vp) late vaccine two (LVT) / ChAdOx1 nCoV-19 0.5mL boost / ChAdOx1 nCoV-19 full boost / ChAdOx1 nCoV-19 half boost / MenACWY / MenACWY boost / Paracetamol 18 Years 1090 2020-04-23 2021-10-15 TRUE TRUE TRUE NCT04324606 COV001, NCT04324606
ChAdOx1 nCoV-19 / Normal saline 0.9% 18 Years 2130 2020-06-24 2020-12-15 TRUE TRUE TRUE NCT04444674 ChAdOx1 nCoV-19_ZA_phI/II v4.1, NCT04444674
ChAdOx1 nCoV-19 single dose + paracetamol / ChAdOx1 nCoV-19 two dose + paracetamol / MenACWY prime & saline placebo boost + paracetamol / MenACWY single dose + paracetamol 18 Years 10300 2020-06-02 2021-09-15 TRUE TRUE TRUE NCT04536051 COV003, NCT04536051
COMIRNATY - BioNTech Manufacturing GmbH / COVID-19 Vaccine AstraZeneca suspension for injection / COVID-19 Vaccine Moderna dispersion for injection - MODERNA BIOTECH 18 Years 10000 2021-02-08 2024-12-31 FALSE FALSE FALSE NCT04760132 ENFORCE, NCT04760132
CoronaVac / Oxford-AstraZeneca COVID-19 vaccine / Tozinameran 11 Years 900 2021-04-15 2025-03-31 TRUE TRUE FALSE NCT04800133 COVA01, NCT04800133
CoronaVac / Placebo 18 Years 13000 2020-09-14 2021-02-15 TRUE TRUE FALSE NCT04582344 9026-ASI, NCT04582344
COVID-19 serology 18 Years 1000 2021-02-01 2021-09-15 FALSE FALSE FALSE NCT04862806 0214-20-BNZ, NCT04862806
COVID-19 Vaccination / Usual care N/A 4000 2021-04-15 2021-09-15 FALSE FALSE FALSE NCT04818736 2021-RCT, NCT04818736
Covishield 18 Years 2200 2021-03-19 2022-03-19 FALSE TRUE FALSE NCT04794946 ILBS-COVID-05, NCT04794946
COVIV only (1st and 2nd dose) / COVIV+IIV4; COVIV+PPV23 / IIV4 for the 1st dose and PPV23 for the 2nd dose 18 Years 1152 2021-02-23 2021-10-15 TRUE TRUE TRUE NCT04790851 COVIV-PPV23-IIV4-Combine, NCT04790851
CVnCoV / Placebo 18 Years 36500 2020-12-14 2021-03-05 TRUE TRUE TRUE NCT04652102 CV-NCOV-004, 2020-003998-22, NCT04652102
CVnCoV 12 μg / CVnCoV 12μg / CVnCoV 6 μg / Hepatitis A vaccine / Pneumococcal vaccine 18 Years 674 2020-09-28 2021-11-09 TRUE TRUE TRUE NCT04515147 CV-NCOV-002, NCT04515147
CVnCoV Vaccine 18 Years 180 2021-05-14 2021-08-15 TRUE TRUE FALSE NCT04838847 CV-NCOV-012, 2020-005064-54, NCT04838847
CVnCoV Vaccine 18 Years 1200 2021-04-22 2021-09-15 TRUE TRUE TRUE NCT04860258 CV-NCOV-003, 2020-004070-22, NCT04860258
CVnCoV Vaccine / Placebo 18 Years 280 2020-06-18 2021-12-15 TRUE TRUE TRUE NCT04449276 CV-NCOV-001, 2020-001286-36, NCT04449276
CVnCoV Vaccine / Placebo 18 Years 2520 2020-12-23 2021-06-30 TRUE TRUE TRUE NCT04674189 CV-NCOV-005, NCT04674189
Gam-COVID-Vac 18 Years 38 2020-06-17 2020-08-03 TRUE TRUE FALSE NCT04436471 02-Gam-COVID-Vac-2020, NCT04436471
Gam-COVID-Vac 60 Years 110 2020-10-22 2021-03-30 TRUE TRUE FALSE NCT04587219 05-Gam-COVID-Vac-2020, NCT04587219
Gam-COVID-Vac / placebo 18 Years 33758 2020-09-07 2021-05-01 TRUE TRUE FALSE NCT04530396 04-Gam-COVID-Vac-2020, NCT04530396
Gam-COVID-Vac / placebo 18 Years 1000 2020-12-15 2021-08-15 FALSE TRUE TRUE NCT04656613 06-Gam-COVID-Vac-2020, NCT04656613
Gam-COVID-Vac / Placebo 18 Years 100 2020-09-28 2021-03-28 TRUE TRUE FALSE NCT04564716 04-Gam-COVID-Vac-2020-RB, NCT04564716
Gam-COVID-Vac / Placebo 18 Years 1600 2020-11-30 2021-08-15 TRUE TRUE TRUE NCT04640233 RDI-GCV-001, CTRI/2020/11/029234, NCT04640233
Gam-COVID-Vac / Placebo 18 Years 2000 2020-11-15 2021-10-15 TRUE TRUE FALSE NCT04642339 01V-Gam-COVID-Vac-2020, NCT04642339
Gam-COVID-Vac Lyo 18 Years 38 2020-06-17 2020-08-03 TRUE TRUE FALSE NCT04437875 03-Gam-COVID-Vac Lyo-2020, NCT04437875
immunogenicity after first and second dose 18 Years 150 2021-05-10 2021-07-30 FALSE FALSE FALSE NCT04852861 DemiVac2021, 2021-002088-23, NCT04852861
Inactivated SARS CoV 2 vaccine (Vero cell) Wuhan/Beijing/Placebo 18 Years 12000 2020-09-09 2021-02-19 FALSE FALSE TRUE NCT04612972 UPeruanaCH, NCT04612972
Inactivated SARS-CoV-2 Vaccine (Vero cell) / Inactivated SARS-CoV-2 Vaccine (Vero cell) / Placebo 18 Years 45000 2020-07-16 2021-06-16 FALSE FALSE TRUE NCT04510207 CNBG2020003SQ, NCT04510207
Inactivated SARS-CoV-2 Vaccine (Vero cell) / Placebo 18 Years 34020 2021-01-28 2021-09-15 TRUE FALSE TRUE NCT04659239 20200404, NCT04659239
Inactivated SARS-CoV-2 vaccine (Vero cell) / Placebo/Aluminum Adjuvant of Inactivated SARS-CoV-2 vaccine 18 Years 3000 2020-09-16 2021-12-01 FALSE FALSE TRUE NCT04560881 BIBP2020003AR, NCT04560881
Licensed seasonal influenza vaccine / Placebo / SARS-CoV-2 rS/Matrix M1-Adjuvant 18 Years 15000 2020-09-28 2021-01-15 TRUE TRUE TRUE NCT04583995 2019nCoV-302, NCT04583995
Moderna COVID-19 Vaccine 18 Years 37500 2021-03-24 2021-12-22 TRUE TRUE FALSE NCT04811664 CoVPN 3006, NCT04811664
Moderna COVID-19 Vaccine / Pfizer-BioNTech COVID-19 Vaccine / Placebo 18 Years 3400 2021-04-07 2021-06-15 TRUE FALSE FALSE NCT04761822 DAIT COVID-19-004, NIAID CRMS ID#: 38814, NCT04761822
Moderna COVID-19 Vaccine, mRNA-1273 (100 μg) / Pfizer-BioNTech COVID-19 Vaccine BNT162b2 (30 µg)( Comirnaty®) 18 Years 380 2021-04-19 2022-07-15 FALSE FALSE FALSE NCT04805125 2021-000593; me20Bucher, NCT04805125
Moderna mRNA-1273 vaccine / REGN10933+REGN10987 18 Years 180 2021-04-20 2021-07-30 FALSE TRUE FALSE NCT04852978 R10933-10987-COV-2118, NCT04852978
mRNA-1273 18 Years 120 2020-03-16 2022-11-22 TRUE TRUE TRUE NCT04283461 20-0003, 5UM1AI148684-02, NCT04283461
mRNA-1273 18 Years 180 2021-02-10 2021-07-01 TRUE FALSE TRUE NCT04748471 APHP201504, 2020-005889-34, NCT04748471
mRNA-1273 18 Years 120 2021-04-28 2022-01-01 TRUE TRUE FALSE NCT04847050 10000115, 000115-C, NCT04847050
mRNA-1273 18 Years 240 2021-04-16 2021-08-26 TRUE TRUE FALSE NCT04860297 mRNA-1273-P304, NCT04860297
mRNA-1273 / mRNA-1273.351 18 Years 210 2021-03-29 2022-08-31 TRUE TRUE TRUE NCT04785144 21-0002, NCT04785144
mRNA-1273 SARS-CoV-2 vaccine from Moderna 18 Years 873 2021-01-08 2021-07-15 TRUE FALSE TRUE NCT04715438 202000865, NCT04715438
mRNA-1273 vaccine vs Normal Saline Placebo 18 Years 120 2021-05-17 2021-07-30 FALSE FALSE FALSE NCT04885907 21-5324.0, NCT04885907
Normal saline solution (NSS), Placebo - Phase 1 / Normal saline solution (NSS), Placebo - Phase 2 / Normal saline solution (NSS), Placebo, Day 189 - Phase 2 / Normal saline solution (NSS), Placebo, Day 21 - Phase 1 / Normal saline solution (NSS), Placebo, Day 21 - Phase 2 / SARS-CoV-2 rS - Phase 1 / SARS-CoV-2 rS/Matrix-M Adjuvant - Day 189 - Phase 2 / SARS-CoV-2 rS/Matrix-M Adjuvant - Phase 1 / SARS-CoV-2 rS/Matrix-M Adjuvant, Day 0 - Phase 1 / SARS-CoV-2 rS/Matrix-M Adjuvant, Day 0 - Phase 2 / SARS-CoV-2 rS/Matrix-M Adjuvant, Days 0 and 21 - Phase 2 18 Years 1419 2020-05-25 2020-12-01 TRUE TRUE TRUE NCT04368988 2019nCoV-101, NCT04368988
one dose of BNT162b2 vaccine / two doses of BNT162b2 vaccine 18 Years 300 2021-03-08 2021-08-08 TRUE FALSE TRUE NCT04824638 ANRS0002S, NCT04824638
Placebo (Crossover Vaccination period) / Placebo (Initial Vaccination Period) / SARS-CoV-2 rS/Matrix-M1 Adjuvant (Crossover Vaccination period) / SARS-CoV-2 rS/Matrix-M1 Adjuvant (Initial Vaccination Period) 12 Years 33000 2020-12-27 2023-06-30 TRUE TRUE TRUE NCT04611802 2019nCoV-301, NCT04611802
Placebo / high dosage inactivated SARS-CoV-2 vaccine / medium dosage inactivated SARS-CoV-2 vaccine 18 Years 1000 2020-10-27 2021-06-30 FALSE FALSE TRUE NCT04756323 2020L001-1B, NCT04756323
Placebo / high dosage inactivated SARS-CoV-2 vaccine / medium dosage inactivated SARS-CoV-2 vaccine 18 Years 180 2020-10-07 2021-06-30 FALSE FALSE TRUE NCT04758273 2020L001-1A, NCT04758273
Placebo / mRNA-1273 18 Years 30420 2020-07-27 2022-10-27 TRUE FALSE FALSE NCT04470427 mRNA-1273-P301, 75A50120C00034, NCT04470427
Placebo / mRNA-1273 12 Years 3000 2020-12-09 2022-06-30 TRUE TRUE TRUE NCT04649151 mRNA-1273-P203, NCT04649151
Placebo / mRNA-1273 6 Months 6750 2021-03-15 2023-06-10 FALSE TRUE FALSE NCT04796896 mRNA-1273-P204, NCT04796896
Placebo / mRNA-1273 / mRNA-1283 18 Years 125 2021-03-11 2022-04-13 TRUE TRUE FALSE NCT04813796 mRNA-1283-P101, NCT04813796
Placebo / Quadrivalent influenza vaccine (QIV) / SARS-CoV-2 mRNA Vaccine (CVnCoV) 60 Years 1000 2021-05-10 2021-09-27 TRUE TRUE TRUE NCT04848467 21819, NCT04848467
Placebo / SARS-CoV-2 Inactivated Vaccine 3 Years 500 2021-05-03 2021-07-15 TRUE FALSE TRUE NCT04884685 PRO-nCOV-2001, NCT04884685
Placebo / SARS-CoV-2 rS/Matrix-M1 Adjuvant 18 Years 4400 2020-08-17 2021-11-15 TRUE TRUE TRUE NCT04533399 2019nCoV-501, NCT04533399
Placebo / SARS-CoV-2 Vaccine (Vero Cells), Inactivated 18 Years 28000 2021-05-15 2021-11-15 TRUE TRUE TRUE NCT04852705 2021L001, NCT04852705
To monitor the effectiveness of the single dose Ad26.COV2.S COVID-19 vaccine 18 Years 500000 2021-02-18 2022-03-31 FALSE TRUE FALSE NCT04838795 Sisonke (Together): OPEN LABEL, NCT04838795
Two doses of high dosage inactivated SARS-CoV-2 vaccine at the schedule of day 0,28 / Two doses of low dosage inactivated SARS-CoV-2 vaccine at the schedule of day 0,28 / Two doses of medium dosage inactivated SARS-CoV-2 vaccine at the schedule of day 0,28 / Two doses of placebo at the schedule of day 0,28 60 Years 422 2020-05-22 2020-08-28 TRUE FALSE TRUE NCT04383574 PRO-nCOV-1002, NCT04383574
Two doses of inactivated SARS-CoV-2 vaccine at the schedule of day 0,28 and one dose Quadrivalent Influenza Vaccine on day 0 or day 28. / Two doses of inactivated SARS-CoV-2 vaccine at the schedule of day 0,28 and one dose Quadrivalent Influenza Vaccine on day 14. 18 Years 480 2021-03-15 2021-07-15 TRUE TRUE TRUE NCT04801888 PRO-QINF-4001, NCT04801888
Two doses of low dosage inactivated SARS-CoV-2 vaccine at the schedule of day 0,28 / Two doses of medium dosage inactivated SARS-CoV-2 vaccine at the schedule of day 0,28 / Two doses of placebo at the schedule of day 0,28 3 Years 552 2020-10-31 2021-02-15 TRUE TRUE TRUE NCT04551547 PRO-nCOV-1003, NCT04551547

References

Madhusoodhan, P. Pallavi, Joanna Pierro, Jordan Musante, Prachi Kothari, Bradley Gampel, Burton Appel, Adam Levy, et al. 2020. “Characterization of COVID-19 Disease in Pediatric Oncology Patients: The New York-New Jersey Regional Experience.” Pediatric Blood & Cancer, December, e28843. https://doi.org/10.1002/pbc.28843.
Jiang, Li, Kun Tang, Mike Levin, Omar Irfan, Shaun K. Morris, Karen Wilson, Jonathan D. Klein, and Zulfiqar A. Bhutta. 2020. “COVID-19 and Multisystem Inflammatory Syndrome in Children and Adolescents.” The Lancet. Infectious Diseases 20 (11): e276–88. https://doi.org/10.1016/S1473-3099(20)30651-4.
Herold, Ralf. 2018. Ctrdata: R Package to Aggregate and Analyse Information on Clinical Trials from Public Registers. https://github.com/rfhb/ctrdata.


Leave a Reply

Your email address will not be published.